EDSP Public Discussion

EPA has published the Agenda for the EDSP SAP

The Agenda is attached here.

Click here for FIFRA SAP Roster.

“It has been EPA’s practice, and often a legal requirement, for the Agency to provide adequate notice and opportunity for comment when the Agency undertakes a significant action or scientific review. In the case of the upcoming SAP review, adequate Agency notice includes providing the public the technical documents that are the basis of the review. The public has a meaningful opportunity to comment only when those documents are provided sufficiently prior to the SAP for substantive technical review and analysis. Sufficient time for public review will assist the SAP and Agency to address the critical scientific and policy issues at hand. EPA has implemented a truncated review process that will bypass robust public review and inhibit adequate peer review. By any standard, this is not acceptable. This is inconsistent with existing procedural standards and is contrary to President Obama’s commitment to scientific integrity, transparency and public participation. We urge EPA to rectify this situation.”

This memo transmits the charge questions, issue paper, and related documents for the January 29–Febuary 1, 2013 FIFRA Scientific Advisory Panel “Prioritization of the Endocrine Disruptor Screening Program Universe of Chemicals for an Estrogen Receptor Adverse Outcome Pathway Using Computational Toxicology Tools.”

 These documents include the White Paper, which is being provided for the Panel’s review, along with referenced materials. Additionally, these documents have been electronically transmitted to you via email.

These documents do not contain any information protected under the statute as Confidential Business Information (CBI) or information protected from disclosure to foreign and multi-national pesticide producers under FIFRA Section 10(gThe attached CD contains the documents identified in the table below. Please feel free to call upon us if you have any questions

Scientific Issues Associated with Prioritizing the Universe of Endocrine Disruptor Screening Program (EDSP) Chemicals Using Computational Toxicology Tools

The agency intends to screen those chemicals which have the greatest potential to interact with the endocrine systems in humans and other species. To that end, EPA has proposed an approach to determine the order in which to screen certain classes of chemicals (

e.g., drinking water contaminants and pesticide inert ingredients, including fragrances) using the Tier 1 battery under EPA’s Endocrine Disruptor Screening Program (EDSP). This proposed chemical prioritization process uses existing information including physicochemical properties and exposure information together with information from computational toxicology methods, including in silico expert systems, effects-based chemical category and read-across concepts, and empirical in vitro

Prioritization

Section 1 to 3

Section 4

Appendix A

 Appendix B