David Burns, MD (UCSD, School of Medicine, Professor Emeritus) (9:00 am) noted that the WHO list of the most hazerdoous tobacco constitutents was not based solely on toxicology per se as the list was developed for regulatory purposes.

– Clifford Watson, Ph.D. (CDC) (11:20am) stated that “we would want to use the best available science to decide this list of harmful constituents.”

– Dr. Burns, (11:40am) stated that animal toxicity data is not a reliable predictor of human toxicity.

–Henningfield (2:10 pm) indicated that “the degree to which menthol may initiate or promote dependence” should be considered in deciding whether it listed as harmful. Response from Burns: We should leave to the parent committee the menthol decision.

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